Hydrophilic interaction chromatography
نویسندگان
چکیده
In the early 1990s, hydrophilic interaction (liquid) chromatography (HILIC) emerged as a new separation method. HILIC is becoming increasingly popular for the separation of polar compounds in aqueous-organic mobile phases rich in organic solvents (usually acetonitrile). It has become important for the separation of pharmaceuticals, neurotransmitters, nucleosides, nucleotides and other compounds. This review presents an overview of HILIC separation systems, comparing it to several other recently described modes. a 2012 Elsevier Ltd. All rights reserved.
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There is no other naturally occurring defense agent against cancer that has a stronger effectthan paclitaxel, commonly known under the brand name of Taxol®. The major drawback for themore widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DABIII), is that they require large-scale extraction from different parts of yew trees (Taxus species),cell cultures, taxane...
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499: 177. Lindner H, Sarg B and Helliger W (1997) Application of hydrophilic-interaction liquid chromatography to the separation of phosphorylated H1 histones. Journal of Chromatography 728: 55. Mant CT and Hodges RS (eds) (1991) High-performance Liquid Chromatography of Peptides and Proteins: Separation, Analysis, and Conformation. Boca Raton: CRC Press. Mant CT and Hodges RS (1996) Analysis o...
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